A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT
Epithelial-to-mesenchymal transition (EMT) is a fundamental process whereby epithelial cells acquire mesenchymal phenotypes and the ability to migrate.EMT is the hallmark of gastrulation, an COLD evolutionarily conserved developmental process.In mammals, epiblast cells ingress at the primitive streak to form mesoderm.Cells ingress and exit the epib